Research Article: Ethyl 2-benzyl-3-[3-(4-chloro­phen­yl)-1-phenyl-1H-pyrazol-4-yl]-4,6-dioxo-5-phenyl­octa­hydro­pyrrolo­[3,4-c]pyrrole-1-carboxyl­ate

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): P. Kamatchi, G. Jagadeesan, M. Pramesh, P. T. Perumal, S. Aravindhan.


The title compound, C37H31ClN4O4, crystallizes with two mol­ecules (A and B) in the asymmetric unit. The pyrrole rings in both mol­ecules are connected via cis fusion, whereas one ring has a twisted conformation and the other assumes a half-chair conformation. In the crystal, the A mol­ecules form inversion dimers via a pair of C—H⋯Cl inter­actions, while the B mol­ecules form chains propagating in [10], via C—H⋯O inter­actions. In the crystal, there are also a number of C—H⋯π inter­actions present.

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For the bioactivity of pyrazole derivatives, see: Sullivan et al. (2006 ▶); Patel et al. (2010 ▶); Siu et al. (2008 ▶). For conformation studies, see: Nardelli (1983 ▶).