Research Article: Ethyl 4-cyano-7-nitro-1,2,3,3a,4,5-hexa­hydro­pyrrolo­[1,2-a]quinoline-4-carboxyl­ate

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): Yvon Bibila Mayaya Bisseyou, Adéyolé Timotou, Ajouby Adjou, Rita Kakou-Yao, Jules Tenon Abodou.

http://doi.org/10.1107/S1600536812003480

Abstract

In the title compound, C16H17N3O4, the six-membered N-containing ring adopts a half-chair conformation. One C atom of the five-membered ring is disordered over two sites, with occupancy factors of ca 0.67 and 0.33. The major pyrroline component adopts a half-chair conformation. Inter­molecular C—H⋯O hydrogen bonds forming centrosymmetric dimers are observed in the crystal.

Partial Text

For the biological activity of tricyclic quinoline derivatives, see: Dalla Via et al. (2008 ▶); Gasparotto et al. (2006 ▶); Ferlin et al. (2000 ▶). For the crystal structure of an inter­mediate compound, see: Yapo, Konan et al. (2010 ▶). For a closely related crystal structure, see: Yapo, Abou et al. (2010 ▶). For ring conformation analysis, see: Cremer & Pople (1975 ▶). For graph-set notation, see: Bernstein et al. (1995 ▶).

 

Source:

http://doi.org/10.1107/S1600536812003480