Date Published: May 01, 2010
Publisher: International Union of Crystallography
Author(s): Xiao-Ping Song, Gong-Chun Li, Chang-Zeng Wu, Feng-Ling Yang.
The title compound, C16H20F3N3O4, was prepared by reaction of 4-(dimethylamino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and urea. In the title molecule, the pyrimidine ring adopts a half-chair conformation and there is an intramolecular hydrogen bond (O—H⋯O). The crystal structure is stabilized by two types intermolecular hydrogen bonds (N—H⋯O and N—H⋯N).
For the bioactivity of dihydropyrimidines, see: Brier et al. (2004 ▶); Cochran et al. (2005 ▶); Moran et al. (2007 ▶); Zorkun et al. (2006 ▶). For the bioactivity of organofluorine compounds, see: Hermann et al. (2003 ▶); Ulrich (2004 ▶).