Research Article: Ethyl 6-[4-(dimethyl­amino)phen­yl]-4-hydr­oxy-2-oxo-4-(trifluoro­methyl)­hexa­hydro­pyrimidine-5-carboxyl­ate

Date Published: May 01, 2010

Publisher: International Union of Crystallography

Author(s): Xiao-Ping Song, Gong-Chun Li, Chang-Zeng Wu, Feng-Ling Yang.

http://doi.org/10.1107/S1600536810013127

Abstract

The title compound, C16H20F3N3O4, was prepared by reaction of 4-(dimethyl­amino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxo­butanoate and urea. In the title mol­ecule, the pyrimidine ring adopts a half-chair conformation and there is an intra­molecular hydrogen bond (O—H⋯O). The crystal structure is stabilized by two types inter­molecular hydrogen bonds (N—H⋯O and N—H⋯N).

Partial Text

For the bioactivity of dihydro­pyrimidines, see: Brier et al. (2004 ▶); Cochran et al. (2005 ▶); Moran et al. (2007 ▶); Zorkun et al. (2006 ▶). For the bioactivity of organofluorine compounds, see: Hermann et al. (2003 ▶); Ulrich (2004 ▶).

 

Source:

http://doi.org/10.1107/S1600536810013127

 

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