Research Article: Ethyl 6-methyl-2-sulfanyl­idene-4-[4-(trifluoro­meth­yl)phen­yl]-1,2,3,4-tetra­hydro­pyrimidine-5-carboxyl­ate

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Susanta K. Nayak, K. N. Venugopala, Thavendran Govender, Hendrik G. Kruger, Glenn E. M. Maguire, T. N. Guru Row.


The title compound, C15H15F3N2O2S, adopts a conformation with an intra­molecular C—H⋯π inter­action. The dihedral angles between the planes of the 4-(trifluoro­meth­yl)phenyl and ester groups with the plane of the six-membered tetra­hydro­pyrimidine ring are 81.8 (1) and 16.0 (1)°, respectively. In the crystal structure, inter­molecular N—H⋯S hydrogen bonds link pairs of mol­ecules into dimers and N—H⋯O inter­actions generate hydrogen-bonded mol­ecular chains along the crystallographic a axis.

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For applications of multi-functionalized dihydro­pyrimidines, see: Jauk et al. (2000 ▶); Kappe (2000 ▶); Mayer et al. (1999 ▶). For structural analysis, see: Nayak et al. (2009 ▶, 2010 ▶).




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