Date Published: July 01, 2011
Publisher: International Union of Crystallography
Author(s): Susanta K. Nayak, K. N. Venugopala, Thavendran Govender, Hendrik G. Kruger, Glenn E. M. Maguire, T. N. Guru Row.
The title compound, C15H15F3N2O2S, adopts a conformation with an intramolecular C—H⋯π interaction. The dihedral angles between the planes of the 4-(trifluoromethyl)phenyl and ester groups with the plane of the six-membered tetrahydropyrimidine ring are 81.8 (1) and 16.0 (1)°, respectively. In the crystal structure, intermolecular N—H⋯S hydrogen bonds link pairs of molecules into dimers and N—H⋯O interactions generate hydrogen-bonded molecular chains along the crystallographic a axis.
For applications of multi-functionalized dihydropyrimidines, see: Jauk et al. (2000 ▶); Kappe (2000 ▶); Mayer et al. (1999 ▶). For structural analysis, see: Nayak et al. (2009 ▶, 2010 ▶).