Research Article: Ethyl 7′-(6-benz­yloxy-2,2-dimethyl­tetra­hydro­furo[3,2-d][1,3]dioxol-5-yl)-2-oxo-5′,6′,7′,7a’-tetra­hydro-1′H,2H-spiro­[acenaphthyl­ene-1,5′-pyrrolo­[1,2-c][1,3]thia­zole]-6′-carboxyl­ate

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): G. Jagadeesan, K. Sethusankar, R. Prasanna, R. Raghunathan.

http://doi.org/10.1107/S1600536812032291

Abstract

In the title compound, C34H35NO7S, the acenaphthyl­ene unit is essentially planar (r.m.s. deviation = 0.0335 Å). The pyrrolo­thia­zole ring system is folded about the bridging N—C bond; the thia­zolidine and pyrrolidine rings adopt S- and C-envelope conformations, respectively, with a ‘butterfly’ angle between the mean planes of 51.38 (10)°. The dioxolane and tetra­hydro­furan rings adopt O- and a C-envelope conformations, respectively, with a ‘butterfly’ angle between the mean planes of 57.12 (10)°. Two C atoms are each disordered over two positions with site-occupancy factors of 0.450 (7) and 0.550 (7). The crystal packing is stabilized by C—H⋯O inter­actions, generating an R22(14) graph-set ring motif.

Partial Text

For the biological properties of spiro­heterocycles, see: Kilonda et al. (1995 ▶); Ferguson et al. (2005 ▶). For a related structure, see: Jagadeesan et al. (2012 ▶). For graph-set notation, see: Bernstein et al. (1995 ▶).

 

Source:

http://doi.org/10.1107/S1600536812032291

 

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