Date Published: August 01, 2012
Publisher: International Union of Crystallography
Author(s): G. Jagadeesan, K. Sethusankar, R. Prasanna, R. Raghunathan.
In the title compound, C34H35NO7S, the acenaphthylene unit is essentially planar (r.m.s. deviation = 0.0335 Å). The pyrrolothiazole ring system is folded about the bridging N—C bond; the thiazolidine and pyrrolidine rings adopt S- and C-envelope conformations, respectively, with a ‘butterfly’ angle between the mean planes of 51.38 (10)°. The dioxolane and tetrahydrofuran rings adopt O- and a C-envelope conformations, respectively, with a ‘butterfly’ angle between the mean planes of 57.12 (10)°. Two C atoms are each disordered over two positions with site-occupancy factors of 0.450 (7) and 0.550 (7). The crystal packing is stabilized by C—H⋯O interactions, generating an R22(14) graph-set ring motif.
For the biological properties of spiroheterocycles, see: Kilonda et al. (1995 ▶); Ferguson et al. (2005 ▶). For a related structure, see: Jagadeesan et al. (2012 ▶). For graph-set notation, see: Bernstein et al. (1995 ▶).