Research Article: Ethyl 9-fluoro-5,12-dioxo-5,12-dihydro­indolizino[2,3-g]quinoline-6-carboxyl­ate

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): Da-Li Zhang, Li-Ping Zhang, Jia Yao, Xi-Wei Wu, Lin-Kun An.

http://doi.org/10.1107/S160053681202692X

Abstract

In the title mol­ecule, C18H11FN2O4, the fused four- ring system is essentially planar, with an r.m.s. deviation of 0.032 Å. In the crystal, mol­ecules are connected by π–π stacking inter­actions [centroid–centroid distances = 3.5684 (9) and 3.8247 (9) Å] into chains along [100].

Partial Text

The title compound was obtained in an attempt to synthesize a Top1 (DNA topoisomerase IB) inhibitor. For general background to Top1, see: Pommier (2006 ▶). For the synthesis, see: Shen et al. (2008 ▶); Cheng et al. (2008 ▶). For a related structure, see: Wu et al. (2011 ▶). For the Top1 inhibitory activity of a related indolizinoquinoline-5,12-dione derivative, see: Wu et al. (2010 ▶).

 

Source:

http://doi.org/10.1107/S160053681202692X

 

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