Date Published: August 01, 2012
Publisher: International Union of Crystallography
Author(s): Da-Li Zhang, Li-Ping Zhang, Jia Yao, Xi-Wei Wu, Lin-Kun An.
In the title molecule, C18H11FN2O4, the fused four- ring system is essentially planar, with an r.m.s. deviation of 0.032 Å. In the crystal, molecules are connected by π–π stacking interactions [centroid–centroid distances = 3.5684 (9) and 3.8247 (9) Å] into chains along .
The title compound was obtained in an attempt to synthesize a Top1 (DNA topoisomerase IB) inhibitor. For general background to Top1, see: Pommier (2006 ▶). For the synthesis, see: Shen et al. (2008 ▶); Cheng et al. (2008 ▶). For a related structure, see: Wu et al. (2011 ▶). For the Top1 inhibitory activity of a related indolizinoquinoline-5,12-dione derivative, see: Wu et al. (2010 ▶).