Research Article: Evidence of association of circulating epigenetic-sensitive biomarkers with suspected coronary heart disease evaluated by Cardiac Computed Tomography

Date Published: January 23, 2019

Publisher: Public Library of Science

Author(s): Teresa Infante, Ernesto Forte, Concetta Schiano, Bruna Punzo, Filippo Cademartiri, Carlo Cavaliere, Marco Salvatore, Claudio Napoli, Esther Lutgens.


Circulating biomarkers available in clinical practice do not allow to stratify patients with coronary heart disease (CHD) prior the onset of a clinically relevant event. We evaluated the methylation status of specific genomic segments and gene expression in peripheral blood of patients undergoing Cardiac Computed Tomography (CCT) for CHD (n = 95).

Partial Text

Despite advances in diagnosis, treatment and prognosis, coronary heart disease (CHD) is still the most prevalent cause of mortality and morbidity worldwide [1].

Here, we evaluated in PBMNCs from suspected CHD patients and HS, undergoing CCT, the methylation status of specific regulatory regions in principal genes involved in cholesterol pathway. Furthermore, we have analyzed the mRNA levels of the selected genes.

Our study could have an important clinical impact, representing a possible initial epigenetic/molecular-sensitive approach in the diagnosis and prediction of CHD through a non-invasive approach. Therefore, the evaluation of reproducible and non-invasive techniques for assessing endothelial function should enable screening of large populations and may guide interventions designed specifically to reduce the individual vascular risk.




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