Research Article: Febuxostat methanol solvate

Date Published: May 01, 2011

Publisher: International Union of Crystallography

Author(s): Qi-Ying Jiang, Jing-Jing Qian, Jian-Ming Gu, Gu-Ping Tang, Xiu-Rong Hu.

http://doi.org/10.1107/S1600536811014905

Abstract

In the title compound {systematic name: [2-(3-cyano-4-isobutyl­oxyphen­yl)-4-methyl-1,3-thia­zole-5-carb­oxy­lic acid (febuxostat) methanol monosolvate}, C16H16N2O3S·CH4O, the benzene and thia­zole rings in the febuxostat mol­ecule are twisted at 5.3 (1)°. In the crystal structure, inter­molecular O—H⋯O and O—H⋯N hydrogen bonds link the febuxostat and methanol mol­ecules into helical chains along the 21 screw axis.

Partial Text

For applications of febuxostat in the medicine, see: Schumacher et al. (2009 ▶); Becke et al. (2010 ▶); Khosravan et al. (2007 ▶); Takano et al. (2005 ▶). For the synthesis, polymorphism, stability and bioavailabitily of febuxostat, see: Hiramatsu et al. (2000 ▶); Sorbera et al. (2001 ▶); Zhou et al. (2007 ▶). For the crystal structure of febuxostat pyridine solvate, see: Zhu et al. (2009 ▶).

Source:

http://doi.org/10.1107/S1600536811014905