Date Published: May 16, 2008
Publisher: BioMed Central
Author(s): Henning A Haga, Bjørnar Ytrehus, Inger J Rudshaug, Nina Ottesen.
Neoplasia may cause hypoglycemia in different species including the horse, but hypoglycemia has not previously been reported in the horse associated with gastrointestinal stromal tumours.
A case of a gastrointestinal stromal tumour in a Fjord pony with severe recurrent hypoglycemia is presented. The mechanism causing the hypoglycemia was not established.
This case indicates that a gastrointestinal stromal tumour may cause hypoglycemia also in the horse.
Clinical signs of hypoglycemia in adult equines are unusal. In humans and canines hypoglycemia caused by neoplasia is well established [1,2], a few reports have described this occurrence in the horse [3-7]. Hypoglycemia has not previously been described in association with gastrointestinal stromal tumours in this species. This report describes a horse with a gastrointestinal stromal tumour and hypoglycemia.
The morphological and immunohistochemical features of the tumour supported a diagnosis of gastrointestinal stromal tumour (GIST) of the leiomyosarcoma subset [8-11]. The nodules in the heart were considered as metastases from the neoplastic tissue associated with the stomach.
This case indicates that GIST may cause hypoglycemia in the horse.
The authors declare that they have no competing interests.
HAH carried out the clinical examination and treatment and drafted the manuscript. BY carried out the necropsy, IJR performed the immunohistochemical staining and BY did the histological examination. NO carried out the ultrasound examiniation. All authors read and approved the final manuscript.