Research Article: Green Synthesis of Carbon Dots Derived from Walnut Oil and an Investigation of Their Cytotoxic and Apoptogenic Activities toward Cancer Cells

Date Published: March 18, 2018

Publisher: Tabriz University of Medical Sciences

Author(s): Elham Arkan, Ali Barati, Mohsen Rahmanpanah, Leila Hosseinzadeh, Samaneh Moradi, Marziyeh Hajialyani.


Purpose: This paper introduces a green and simple hydrothermal synthesis to prepare carbon quantum dots (CQDs) from walnut oil with a high quantum yield. In addition, cytotoxic and apoptogenic properties of the CQDs were analyzed on human cancer cell lines.

Partial Text

Carbon-based materials have some properties such as good flexibility, high strength and stability and excellent electrical and thermal conductivity. Carbon fibers, fullerene, porous materials, carbon nanotubes and carbon quantum dots are some of the members in the carbon-based family.1 Carbon quantum dots (CQDs) are taken into account as a new class of nano-carbonaceous materials with photoluminescence properties discovered by Xu et al. (2004).2,3

Hydrazine and ammonium bromide were purchased from Merck (Germany). 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazoliumbromide (MTT), rhodamine, caspase 9 substrate and Caspase-3 Detection assay Kit were purchased from Sigma Aldrich (St Louis, MO, USA). Cell culture medium, penicillin–streptomycin, and fetal bovine serum (FBS) were obtained from Gibco (Gibco, Grand Island, NY, USA).

It can be concluded that walnut carbon quantum dots have cytotoxic and apoptotic potential on prostate and breast cancer cells. Therefore, these CQDs may be considered an economical and easily accessible source of effective agents used in cancer chemotherapy.

The authors gratefully acknowledge the research council of Kermanshah University of Medical Sciences for the financial support. This work was performed in partial fulfillment of the requirement for pharm.D of Mohsen Rahmanpanah, in faculty of pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Not applicable.

The authors declare no conflict of interests.




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