Research Article: Hybrid Scaffolds of Hyaluronic Acid and Collagen Loaded with Prednisolone: an Interesting System for Osteoarthritis

Date Published: March 18, 2018

Publisher: Tabriz University of Medical Sciences

Author(s): Farhad Mohammadi, Soliman Mohammadi Samani, Nader Tanideh, Fatemeh Ahmadi.


Purpose: Cartilage regeneration by using polymeric scaffolds is a new option for treatment of osteoarthritis. A good scaffold for tissue engineering should copy the characteristics of natural extracellular matrix. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair.

Partial Text

Defects and injuries of the cartilages are significant causes of dysfunction and disability of knee and other organs. Cartilage diseases such as different types of arthritis affect nearly three quarters of the people during the lifetime.1 Among the various strategies of treating cartilage defects, tissue engineering has grown rapidly thanks to the application of natural, synthetic or hybrid polymers. They are used in scaffolding as space filling agents, delivery vehicles for proteins or drugs, and 3D structures that establish cells and present the stimuli required for tissue regeneration.2

Cartilage diseases and defects like osteoarthritis or rheumatoid arthritis are the most important causes of knee and low back pain. Cartilage degenerative diseases usually need surgeries or other invasive procedures. The use of tissue engineering and biomaterials improve the outcome of therapeutic procedures. Use of biomaterials as scaffolds allows the stem cells or growth factors to attach to the scaffold surface or be load into it.15 Although previous studies evaluated the effect of prednisolone on treatment of osteoarthritis, this material was never loaded into the combined polymeric formulations. The present study developed a porous and mechanically-stable combined scaffold loaded with prednisolone as an anti-inflammatory agent in two usable dosage forms.

Based on the findings of this study, it can be concluded that hybrid formulations are superior to formulations containing HA per se. All of the formulated scaffolds were porous and had interconnected pores, suggesting that the scaffolds are useful for the growth of cells and tissues. Furthermore, increasing the concentration of HA and collagen improves the mechanical properties.

This paper was part of a thesis written by Farhad Mohammadi for the partial fulfillment of PhD degree. It was financially supported by Shiraz University of Medical Sciences (Grant# 94-7585).

Not applicable.

The authors declare no conflict of interests.




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