Research Article: Impact of a Booklet about Diabetes Genetic Susceptibility and Its Prevention on Attitudes towards Prevention and Perceived Behavioral Change in Patients with Type 2 Diabetes and Their Offspring

Date Published: October 13, 2011

Publisher: SAGE-Hindawi Access to Research

Author(s): Masakazu Nishigaki, Eiko Sato, Ryota Ochiai, Taiga Shibayama, Keiko Kazuma.


Background. Offspring of type 2 diabetic patients are at a high risk of type 2 diabetes. Information on diabetes genetic susceptibility and prevention should be supplied to the offspring.
Methods. A six-page booklet on diabetes genetic susceptibility and prevention was distributed to 173 patients who ere ordered to hand it to their offspring. The patients answered a self-administered questionnaire on booklet delivery and attitudinal and behavioral changes toward diabetes and its prevention in themselves and their offspring. Results. Valid responses were obtained from 130 patients. Forty-nine patients had actually handed the booklet. Booklet induces more relief than anxiety. From the patient’s view, favorable attitudinal and/or behavioral changes occurred in more than half of the offspring who were delivered the booklet. Conclusion. The booklet worked effectively on attitudes and behaviors toward diabetes and its prevention both in patients and their offspring. However, the effectiveness of patients as information deliverers was limited.

Partial Text

Type 2 diabetes is a global burden and its etiology is a complex interaction of genetic and environmental factors. Individuals genetically predisposed to type 2 diabetes x are thus important targets for preventive strategies. Genetic understanding of diabetes has drastically progressed through the use of exhaustive methods for searching candidate genes, such as the genome-wide assay [1]. Many investigators have found candidate genes for type 2 diabetes, and most of them show a 1.4-fold increase in individual risk of type 2 diabetes [2]. Recent studies have shown that genotype adds slightly more information to predictive models which consist of common risk factors, including family history [3–6]. So genetic screening using information on individual genetic variants will become technically possible in future, but its usefulness as a predictive factor is still insufficient. In addition, translational research in the field of genetic screening and the discussion about ethical, legal, and social issues are now lagging behind the progress of technology [7, 8].

Among 173 patients who were eligible and who consented to participate in this study, a valid response was obtained only from 130 patients (75.1%). Table 2 shows patient characteristics: male 57.7% (n = 75), mean age 59.9 years (SD = 7.4), and 62.3% patients living with their offspring. The patient disease status was as follows: mean HbA1c 7.2% (SD = 0.9), mean BMI 25.7 (SD = 4.9), one diabetic complication being observed in 15.4%–36.9% of the patients.

The present study investigated utilization of type 2 diabetic patients as information deliverers and the effect of an information delivery tool generated by medical professionals on attitudes towards prevention and perceived behavioral change.




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