Research Article: Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect

Date Published: July 2, 2018

Publisher: Public Library of Science

Author(s): Tanja C. W. Nijboer, Caroline Winters, Boudewijn J. Kollen, Gert Kwakkel, Terence J Quinn.

http://doi.org/10.1371/journal.pone.0198755

Abstract

There is growing evidence that visuospatial neglect (VSN) is associated with lower functional performance in other modalities and is not restricted to the lesioned hemisphere alone, and may also affect the non-lesioned hemisphere in severe first-ever strokes. We aimed to investigate the longitudinal association between the severity of VSN, as reflected by the extent of ipsilesional and contralesional spatial attention deficit, and clinical severity of stroke.

This is a secondary data analysis with merged data from two prospective cohort studies. Resulting in 90 patients and 8 longitudinal measurements at 1, 2, 3, 4, 5, 8, 12, and 26 weeks post-stroke onset. A letter cancellation test (LCT) was used as the primary outcome measure to demonstrate presence and severity of VSN. The clinical severity of stroke was classified using the Bamford Classification.

No significant association between clinical severity and the number of ipsilesional, as well as contralesional, omissions on the LCT was observed. Recovery of VSN at the contralesional hemiplegic, as well as ipsilesional non-hemiplegic side, was only dependent on ‘time’ as a reflection of spontaneous neurobiological recovery post-stroke. The recovery of the ipsilesional extension of VSN was significantly slower for the total anterior circulation infarct (TACI) group compared to the non-TACI group.

Larger strokes have a significant negative impact on recovery of visual attention at the non-hemiplegic side. No clinical determinants that regulate spontaneous time-dependent recovery of VSN were found. While early ‘stroke severity’ has been regarded as a strong predictor of functional outcome at a group level, other prognostic factors (demographic, stroke related) need to be determined.

EXPLICIT-stroke Trial: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1424

Partial Text

Visuospatial neglect (VSN) is a frequent disorder following stroke, leaving patients with impaired or even lost awareness for contralesional stimuli and/or events (i.e. side of space opposite to the lesioned hemisphere). In very severe cases of VSN, the deficit may also encompass stimuli and/or events at the ipsilesional side, in other words, the same side of space as the lesioned hemisphere. Either due to hypo-attention to the contralesional field [1, 2], hyper-attention to the ipsilesional field [3] or attentional imbalance and hemispheric rivalry [4, 5]. At the behavioural level this results in comparable observations, leaving patients with VSN with a limited magnitude of space that they are aware off.

The current study shows no significant overall association between clinical severity assessed within the first 2 weeks post-stroke onset and the number of ipsilesional, as well as contralesional omissions measured, with the LCT. Recovery of VSN at the contralesional hemiplegic, as well as ipsilesional non-hemiplegic side, was only dependent on ‘time’ as a reflection of spontaneous neurobiological recovery post-stroke. Recovery of VSN at the contralesional and ipsilesional side was comparable between both groups, yet a trend toward lower omission scores was observed for the ipsilesional side only.

 

Source:

http://doi.org/10.1371/journal.pone.0198755

 

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