Research Article: In Situ One‐Pot Synthesis of MOF–Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy

Date Published: April 14, 2018

Publisher: John Wiley and Sons Inc.

Author(s): Dongdong Wang, Huihui Wu, Jiajia Zhou, Pengping Xu, Changlai Wang, Ruohong Shi, Haibao Wang, Hui Wang, Zhen Guo, Qianwang Chen.

http://doi.org/10.1002/advs.201800287

Abstract

Herein, a simple one‐pot way is designed to prepare a type of multifunctional metal–organic framework (MOF)‐based hybrid nanogels by in situ hybridization of dopamine monomer in the skeleton of MnCo. The resultant hybrid nanoparticles (named as MCP) show enhanced photothermal conversion efficiency in comparison with pure polydopamine or MnCo nanoparticles (NPs) synthesized under a similar method and, therefore, show great potential for photothermal therapy (PTT) in vivo. The MCP NPs are expected to possess T1 positive magnetic resonance imaging ability due to the high‐spin Mn‐N6 (S = 5/2) in the skeleton of MnCo. To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arginine–glycine–aspartic acid peptide, respectively: the first one is to increase the stability, biocompatibility, and blood circulation time of MCP NPs in vivo; the second one is to increase the tumor accumulation of MCP‐PEG NPs and improve their therapeutic efficiency as photothermal agent.

Partial Text

The authors declare no conflict of interest.

 

Source:

http://doi.org/10.1002/advs.201800287

 

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