Research Article: KCNQ1OT1 promotes melanoma growth and metastasis

Date Published: April 17, 2018

Publisher: Impact Journals

Author(s): Bingyu Guo, Qian Zhang, Hongyi Wang, Peng Chang, Kai Tao.


Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma.

Partial Text

The incidence and mortality rate of melanoma continues to increase despite advances in drug discovery programs and molecular approaches for identifying drug targets [1]. In order to effectively treat melanoma, it is necessary to inhibit key mechanistic events which regulate melanoma development, including cell proliferation, survival, angiogenesis, invasion, and metastasis [2].

Melanoma cancer has a survival rate less than 5% after metastasis [16]. Understanding the dynamic interaction of pathways will help us identify promising molecular targets for critical barriers to cancer therapy and clinical treatment [17]. lncRNAs can promote apoptosis, proliferation, cell migration, and invasion.




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