Research Article: Life Course Trajectories of Systolic Blood Pressure Using Longitudinal Data from Eight UK Cohorts

Date Published: June 14, 2011

Publisher: Public Library of Science

Author(s): Andrew K. Wills, Debbie A. Lawlor, Fiona E. Matthews, Avan Aihie Sayer, Eleni Bakra, Yoav Ben-Shlomo, Michaela Benzeval, Eric Brunner, Rachel Cooper, Mika Kivimaki, Diana Kuh, Graciela Muniz-Terrera, Rebecca Hardy, Mark J. Caulfield

Abstract: Analysis of eight population-based and occupational cohorts from the UK reveals the patterns of change of blood pressure in the population through the life course.

Partial Text: Systolic blood pressure (SBP) is an important indicator of cardiovascular function as it has a strong, positive, and continuous relationship with cardiovascular disease (CVD) and mortality [1]. In prospective studies that measured SBP in adolescence or early adulthood, SBP has been shown to predict future risk of CVD with the same magnitude of association as that seen in studies measuring blood pressure (BP) in middle age [2]–[5]. Despite a tendency for SBP to track through life [6],[7], randomised controlled trials demonstrate that it is a highly modifiable risk factor [8]. Understanding the progression of SBP through life and factors affecting this progression is clearly important to determining the best methods for preventing future CVD.

Data are from 30,372 individuals comprising 102,583 data points (Table 2). Each cohort was overlapped to some extent by at least one other cohort with data at a similar age. The birth dates of the cohorts spanned the years 1918 to 1992, and BP data were collected over a 29-y period from 1979 to 2008 (Table 3). The oldest T-07 cohort (1932/1933) and the HAS and CaPS cohorts had the highest proportion of individuals working in manual occupations (Table 3) and were more likely to be from the manual social classes in childhood, reflecting secular changes in the UK labour market. WHII is predominantly a white collar cohort, with less than 10% employed in manual occupations and none in classes IV and V.

Source:

http://doi.org/10.1371/journal.pmed.1000440

 

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