Research Article: Long-term trends in incidence and risk factors for ischaemic stroke subtypes: Prospective population study of the South London Stroke Register

Date Published: October 5, 2018

Publisher: Public Library of Science

Author(s): Hatem A. Wafa, Charles D. A. Wolfe, Anthony Rudd, Yanzhong Wang, Joshua Z. Willey

Abstract: BackgroundAs the average life expectancy increases, more people are predicted to have strokes. Recent studies have shown an increasing incidence in certain types of cerebral infarction. We aimed to estimate time trends in incidence, prior risk factors, and use of preventive treatments for ischaemic stroke (IS) aetiological subtypes and to ascertain any demographic disparities.Methods and findingsPopulation-based data from the South London Stroke Register (SLSR) between 2000 and 2015 were studied. IS was classified, based on the underlying mechanism, into large-artery atherosclerosis (LAA), cardio-embolism (CE), small-vessel occlusion (SVO), other determined aetiologies (OTH), and undetermined aetiologies (UND). After calculation of age-, sex-, and ethnicity-specific incidence rates by subtype for the 16-year period, we analysed trends using Cochran-Armitage tests, Poisson regression models, and locally estimated scatterplot smoothers (loess). A total of 3,088 patients with first IS were registered. Between 2000–2003 and 2012–2015, the age-adjusted incidence of IS decreased by 43% from 137.3 to 78.4/100,000/year (incidence rate ratio [IRR] 0.57, 95% CI 0.5–0.64). Significant declines were observed in all subtypes, particularly in SVO (37.4–18; p < 0.0001) and less in CE (39.3–25; p < 0.0001). Reductions were recorded in males and females, younger (<55 years old) and older (≥55 years old) individuals, and white and black ethnic groups, though not significantly in the latter (144.6–116.2; p = 0.31 for IS). A 4-fold increase in prior-to-stroke use of statins was found (adjusted odds ratio [OR] 4.39, 95% CI 3.29–5.86), and despite the increasing prevalence of hypertension (OR 1.54, 95% CI 1.21–1.96) and atrial fibrillation (OR 1.7, 95% CI 1.22–2.36), preventive use of antihypertensive and antiplatelet drugs was declining. A smaller number of participants in certain subgroup-specific analyses (e.g., black ethnicity and LAA subtype) could have limited the power to identify significant trends.ConclusionsThe incidence of ISs has been declining since 2000 in all age groups but to a lesser extent in the black population. The reported changes in medication use are unlikely to fully explain the reduction in stroke incidence; however, innovative prevention strategies and better management of risk factors may contribute further reduction.

Partial Text: Stroke is the second most common cause of death, accounting for 6.24 million deaths globally in 2015 [1]. It is also a leading cause of dependence and disability, ranked third worldwide [2]. In developed countries, most incident and prevalent cases are due to ischaemia, up to 87% and 81% respectively [3–5], and despite the reported decline in ischaemic stroke (IS) incidence [6–8], the absolute burden of the disease is expected to rise substantially as populations continue to grow and live longer [7].

The community-based data from a large and diverse population of south London show a significant decrease in the annual incidence of first-ever ISs in the 2000–2015 period. The reductions were unequally shared between different demographic subgroups; no significant declines were found in the black population (only a modest decrease in SVO). These findings were despite an increased frequency of most cardiovascular risk factors for IS, except for a trend toward lower tobacco smoking and alcohol consumption.

Source:

http://doi.org/10.1371/journal.pmed.1002669

 

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