Research Article: Methyl 1-ethyl-7-methyl-4-oxo-1,4-di­hydro-1,8-naphthyridine-3-carboxyl­ate monohydrate

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Rehana Yasmeen, Muhammad Zia-ur-Rehman, Muhammad Azim Khattak, Muhammad Nadeem Arshad, Islam Ullah Khan.


In the structure of the title compound, C13H14N2O3·H2O, all atoms of the organic molecule except the terminal methyl group of the ethyl group attached to the N atom of the pyridinone ring are roughly coplanar, with an r.m.s. deviation of 0.0897 Å. In the crystal, C—H⋯O contacts link pairs of naphthyridine mol­ecules into head-to-tail dimers. These are joined by strong O—H⋯O hydrogen bonds from the water molecules into infinite chains along the a axis.

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For the coordination properties of 1,8-naphthyridine ligands, see: Gavrilova & Bosnich (2004 ▶); Mintert & Sheldrick (1995 ▶). For their biological activity, see: Chen et al. (2001 ▶); Ferrarini et al. (2000 ▶); Roma et al. (2000 ▶). For related structures, see: Deeba, Khan, Zia-ur-Rehman, Çaylak & Şahin (2009 ▶); Deeba, Khan, Zia-ur-Rehman, Şahin & Çaylak (2009 ▶). For graph-set notation, see: Bernstein et al. (1995 ▶).