Research Article: Methyl 2-acetamido-2-(4-hy­droxy-2-methyl-1,3-dioxo-1,2,3,4-tetra­hydro­isoquinolin-4-yl)-4-methyl­penta­noate

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Hoong-Kun Fun, Ching Kheng Quah, Kai Xu, Yan Zhang.


In the isoquinoline ring system of the title mol­ecule, C19H24N2O6, the N-heterocyclic ring is in a half-boat conformation. The mol­ecular structure is stabilized by an intra­molecular O—H⋯O hydrogen bond, which generates an S(7) ring motif. In the crystal, mol­ecules are linked via inter­molecular bifurcated N—H⋯(O,O) and weak C—H⋯O hydrogen bonds into a three-dimensional network.

Partial Text

For general background to and the potential biological activity of title compound, see: Yu et al. (2010 ▶); Huang et al. (2011 ▶); Rao et al. (1995 ▶); Nagamitsu et al. (1996 ▶); Evans & Weber (1986 ▶); Heimgartner (1991 ▶); Rando (1975 ▶); Griesbeck et al. (2003 ▶); Zhang et al. (2004 ▶); Wang et al. (2010 ▶). For the stability of the temperature controller used in the data collection, see: Cosier & Glazer (1986 ▶). For standard bond-length data, see: Allen et al. (1987 ▶). For ring conformations, see: Cremer & Pople (1975 ▶). For related structures, see: Fun et al. (2011a ▶,b ▶,c ▶,d ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).




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