Research Article: Methyl 2-amino-4-(3-chloro­prop­oxy)-5-methoxy­benzoate

Date Published: May 01, 2009

Publisher: International Union of Crystallography

Author(s): Min Zhang, Ran-zhe Lu, Lu-na Han, Wen-bin Wei, Hai-bo Wang.


The asymmetric unit of the title compound, C12H16ClNO4, contains two crystallographically independent mol­ecules. The benzene rings of the two independent mol­ecules are oriented at a dihedral angle of 88.50 (3)°. Intra­molecular N—H⋯O hydrogen bonds involving the methoxybenzoate carbonyl group in each molecule result in the formation of two planar, six-membered rings, oriented at dihedral angles of 1.39 (3) and 0.68 (3)° with respect to the adjacent benzene rings. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains along the a axis.

Partial Text

For general background to quinazoline derivatives, see: Knesl et al. (2006 ▶). For bond-length data, see: Allen et al. (1987 ▶).




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