Research Article: Minimally Invasive Autopsy: A New Paradigm for Understanding Global Health?

Date Published: November 22, 2016

Publisher: Public Library of Science

Author(s): Peter Byass

Abstract: Peter Byass reflects on the potential niche for minimally invasive autopsies in determining cause-of-death in low- and middle-income countries.

Partial Text: MIA enters the domain of cause-of-death assignment as a new concept among established approaches. A full postmortem examination of a body, often called an autopsy (etymologically “to see for oneself”), is often assumed to be the gold standard for determining cause of death, even though pathology findings frequently differ from clinical diagnoses [6]. There is substantial evidence that full autopsies can reveal otherwise unavailable information about a death, but families are not always comfortable with having an autopsy performed [7]. However, noninvasive (e.g., radiological) techniques may also sometimes reveal disease processes not found in an autopsy [8]. The majority of the world’s cause-of-death assignments are made by physicians issuing a death certificate, in some cases with minimal knowledge of the patient and the final illness and with consequently variable validity, particularly in relation to specific infectious aetiologies. Causes like “old age” or “heart failure” may be factual but are not epidemiologically informative. In locations where physician certificates are not mandatory, typically in low- and middle-income countries, verbal autopsy (undertaking a lay interview with appropriate informants and processing data to assign cause of death) can be used as a low-cost approach to determining cause of death. WHO has led the development of international standards for verbal autopsy, though it remains a relatively imprecise approach [9].

As the field of MIA develops, standard procedures to be followed are still a matter of discussion. For deaths occurring in hard-to-reach areas of low- and middle-income countries, the inclusion of procedures requiring extensive infrastructure, such as advanced radiology, may be impossible. Thus, MIA protocols relying principally on needle sampling have been proposed for low- and middle-income countries [10]. Whether this approach will be adequate for tracking the increasing incidence of deaths from noncommunicable diseases in low-resource settings remains as an important question to answer.

Whether MIA will eventually become a widely used routine practice remains a moot point at this stage. Even if undertaking a MIA exam were to cost less than, say, US$1,000 in a more routine context, the expenditure could still represent a considerable opportunity cost in relation to costs of routine preventive actions such as vaccination. But there may also be another scenario, one in which limited series of MIA exams undertaken in conjunction with carefully conducted verbal autopsy interviews might contribute to an international reference database. One of the difficulties faced by verbal autopsy methods is the lack of definitive connections between characteristics of final illnesses and specific causes of death, even within data specifically gathered for this purpose [11]. If MIA with verbal autopsy were able to determine particular associations between symptoms and aetiologies leading to death, such data (on a sufficiently large scale) could be hugely informative for improving future verbal autopsy standards and models. That in turn could make large-scale and reliable cause-of-death assignment much more viable and cost-effective.



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