Research Article: Missense Mutations in the MEFV Gene Are Associated with Fibromyalgia Syndrome and Correlate with Elevated IL-1β Plasma Levels

Date Published: December 30, 2009

Publisher: Public Library of Science

Author(s): Jinong Feng, Zhifang Zhang, Wenyan Li, Xiaoming Shen, Wenjia Song, Chunmei Yang, Frances Chang, Jeffrey Longmate, Claudia Marek, R. Paul St. Amand, Theodore G. Krontiris, John E. Shively, Steve S. Sommer, Derya Unutmaz.

Abstract: Fibromyalgia syndrome (FMS), a common, chronic, widespread musculoskeletal pain disorder found in 2% of the general population and with a preponderance of 85% in females, has both genetic and environmental contributions. Patients and their parents have high plasma levels of the chemokines MCP-1 and eotaxin, providing evidence for both a genetic and an immunological/inflammatory origin for the syndrome (Zhang et al., 2008, Exp. Biol. Med. 233: 1171–1180).

Partial Text: Fibromyalgia syndrome (FMS) is characterized by chronic, widespread pain in the muscles and joints. FMS is also accompanied by a variety of other common symptoms, including sleep disturbance, fatigue, headache and mood disorders [1]. The prevalence of FMS in the general population is estimated at 2%, where 85% of the affected are females [2]. The current American College of Rheumatology (ACR) criteria for diagnosis/entry into a clinical trial relies on the scoring of 11/18 positive tender points plus widespread pain lasting for more than 3 months [3]. The etiology of FMS is elusive, with proposals ranging from over-sensitivity to pain to chronic infections. Both familial and genetic studies suggest a role for genetic factors in the development of FMS.



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