Research Article: N′-[(1E,2E)-3,7-Dimethyl­octa-2,6-dien-1-yl­idene]pyridine-4-carbohydrazide

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Mashooq A. Bhat, Hatem A. Abdel-Aziz, Hazem A. Ghabbour, Madhukar Hemamalini, Hoong-Kun Fun.


In the title compound, C16H21N3O, the mol­ecule adopts an E conformation about the central C=N double bond. The 2-methyl­pent-2-ene group is disordered over two sets of sites, with a refined occupancy ratio of 0.785 (8):0.215 (8). The dihedral angle between the essentially planar [the r.m.s. value for the major component is 0.021 (7) and its maximum deviation is 0.025 (4) Å; the r.m.s. value for the minor component is 0.03 (4) and its maximum deviation is 0.05 (3) Å] major and minor components of the 2-methyl­but-2-ene group is 35.9 (13)°. In the crystal, C—H⋯O and N—H⋯O hydrogen bonds link the molecules, with the same O atom acting as the acceptor. This results in C11(4) and C11(5) [001] chains.

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For details and the biological activity of isoniazide, see: Janin (2007 ▶); Maccari et al. (2005 ▶); Slayden & Barry (2000 ▶); Hearn et al. (2009 ▶); Tripathi et al. (2011 ▶). For related structures, see: Naveenkumar et al. (2010) ▶; Jiang et al. (2009 ▶); Khan et al. (2009 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).