Research Article: N′-(4-Hydroxy­benzyl­idene)aceto­hydrazide monohydrate

Date Published: August 01, 2009

Publisher: International Union of Crystallography

Author(s): Lu-Ping Lv, Tie-Ming Yu, Wen-Bo Yu, Wei-Wei Li, Xian-Chao Hu.


In the title compound, C9H10N2O2·H2O, the mol­ecular skeleton of the acetohydrazide mol­ecule is nearly planar [within 0.014 (1) Å]. The mol­ecule adopts a trans configuration with respect to the C=N bond, while the side chain is slightly twisted away from the attached ring, forming a dihedral angle of 9.975 (8)°. The crystal packing exhibits a three-dimensional network composed from alternating acetohydrazide mol­ecules and uncoordinated water mol­ecules, which inter­act via N—H⋯O, O—H⋯O and O—H⋯N hydrogen bonds. A C—H⋯π inter­action is also present.

Partial Text

For general background to the analytical applications of Schiff bases, see: Ciemerman et al. (1997 ▶). For their mild bacteriostatic activity and potential use as oral iron-chelating drugs for the treatment of genetic disorders such as thalassemia, see: Offe et al. (1952 ▶); Richardson et al. (1988 ▶). For a related structure, see: Li & Jian (2008 ▶); Tamboura et al. (2009 ▶).




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