Date Published: April 01, 2012
Publisher: International Union of Crystallography
Author(s): Andreas Lemmerer, Joel Bernstein, Volker Kahlenberg.
The title compound, C18H27N3O, is a derivative of the antituberculosis drug isoniazid (systematic name: pyridine-4-carbohydrazidei). The crystal structure consists of repeating C(4) chains along the b axis, formed by N—H⋯O hydrogen bonds with adjacent amide functional groups that are related by a b-glide plane. The cyclododecyl ring has the same approximately ‘square’ conformation, as seen in the parent hydrocarbon cyclododecane.
For hydrogen-bonding motifs, see: Bernstein et al. (1995 ▶). For cycloalkane ring conformations, see: Dale (1966 ▶).