Research Article: N-[2-(4-Bromo­phen­yl)-5-methyl-4-oxo-1,3-thia­zolidin-3-yl]pyridine-3-carboxamide

Date Published: April 01, 2011

Publisher: International Union of Crystallography

Author(s): Mehmet Akkurt, Ísmail Çelik, Hale Demir, Sumru Özkırımlı, Orhan Büyükgüngör.


In the title compound, C16H14BrN3O2S, the atoms of the 1,3-thia­zolidine group, except for the N and the C atoms attached to the bromo­benzene ring, are disordered over two sets of sites with occupancies of 0.605 (13) and 0.395 (13). The benzene and pyridine rings make a dihedral angle of 86.2 (2)°. In the crystal, mol­ecules are linked by inter­molecular N—H⋯N and C—H⋯O hydrogen bonds, forming a three-dimensional network. Furthermore, there is a π–π stacking inter­action [centroid–centroid distance = 3.758 (2) Å] between the pyridine and benzene rings.

Partial Text

For the diverse pharmacological properties of pyridine-3-carboxamides, see: Abdel-Alim et al. (2005 ▶); Girgis et al. (2006 ▶); Slominska et al. (2008 ▶); Spanka et al. (2010 ▶); activities. For the pharmacological properties of 4-thia­zolidinone deriv­atives, see: Vigorita et al. (1992 ▶); Barreca et al. (2003 ▶); Rao et al. (2004 ▶); Jacop & Kutty (2004 ▶); Kalia et al. (2007 ▶).




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