Date Published: April 01, 2011
Publisher: International Union of Crystallography
Author(s): Mehmet Akkurt, Ísmail Çelik, Hale Demir, Sumru Özkırımlı, Orhan Büyükgüngör.
In the title compound, C16H14BrN3O2S, the atoms of the 1,3-thiazolidine group, except for the N and the C atoms attached to the bromobenzene ring, are disordered over two sets of sites with occupancies of 0.605 (13) and 0.395 (13). The benzene and pyridine rings make a dihedral angle of 86.2 (2)°. In the crystal, molecules are linked by intermolecular N—H⋯N and C—H⋯O hydrogen bonds, forming a three-dimensional network. Furthermore, there is a π–π stacking interaction [centroid–centroid distance = 3.758 (2) Å] between the pyridine and benzene rings.
For the diverse pharmacological properties of pyridine-3-carboxamides, see: Abdel-Alim et al. (2005 ▶); Girgis et al. (2006 ▶); Slominska et al. (2008 ▶); Spanka et al. (2010 ▶); activities. For the pharmacological properties of 4-thiazolidinone derivatives, see: Vigorita et al. (1992 ▶); Barreca et al. (2003 ▶); Rao et al. (2004 ▶); Jacop & Kutty (2004 ▶); Kalia et al. (2007 ▶).