Date Published: June 01, 2011
Publisher: International Union of Crystallography
Author(s): Shuang Zhi, Shuai Mu, Ying Liu, Deng-Ke Liu.
In the title compound, C13H16N4OS3, a thienopyridinederivative, the tetrahydropyridine ring exhibits a half-chair conformation, and the folded conformation of the molecule is defined by the N—C—C—N torsion angle of −78.85 (16)°. The crystal packing features intermolecular C—H⋯N, N—H⋯N and C—H⋯O hydrogen bonds.
The title compound is a potential antiplatelet agent. As irreversible P2Y12 antagonists, thienopyridines have proved the relevance of inhibiting signaling via the platelet-specific P2Y12 ADP receptor in the prevention of cardiovascular events, see: Iyengar (2009 ▶); Franchini & Mannucci, (2009 ▶); Van Giezen et al. (2009 ▶); Van Giezen & Humphries (2005 ▶). For a related structure, see: Chen et al. (2010 ▶). For the synthesis of the title compound, see: Liu et al. (2008 ▶).