Research Article: N6,3′-cyclo-5′-O-Cyano­methyl­thymidine

Date Published: June 01, 2010

Publisher: International Union of Crystallography

Author(s): Jingbo Sun, Kun Yang, Ronghui Duan, Jinchang Wu.


The title compound, C19H20N4O4, is a cyclo­nucleoside with a C—N linkage. The furan­ose ring adopts a twist C3′-endo/C2′-exo (close to 3T2) conformation with a pseudorotational phase angle (P) of 8.1° and puckering amplitude (vm) of 30.6°. The orientation of the pyrimidine ring with respect to the sugar group is anti. One intra­molecular C—H⋯O hydrogen bond is observed. The packing features an N—H⋯O hydrogen bond.

Partial Text

For nucleosides, see: Kaur et al. (2007 ▶); Imanishi & Satoshi (2002 ▶); Len et al. (2008 ▶); Mieczkowski et al. (2010 ▶); Sanger (1984 ▶); Altona & Sundaralingam (1972 ▶, 1973 ▶); Zhou & Chattopadhyaya (2009 ▶).




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