Research Article: Neglected Tropical Diseases, Neglected Data Sources, and Neglected Issues

Date Published: November 7, 2007

Publisher: Public Library of Science

Author(s): Burton H. Singer, Carol D. Ryff, Juerg Utzinger

Abstract: None

Partial Text: Given the biomedical roots and disease treatment orientation of the Global Burden of Disease (GBD) framework, as exemplified in the World Bank’s 1993 World Development Report, Investing in Health[1], it is not surprising that we are at a crossroads where whole categories of diseases and a new journal have the adjective “neglected” in their titles. Some of this neglect might have been avoided, even at the outset, if the authors of the 1993 World Development Report had paid attention to the contents of the 1992 World Development Report, which focused on the environment [2]. In virtually every chapter and chapter summary of the 1992 report, issues of health appear, and disease prevention—i.e., reducing the demand for treatment—is center stage. The imbalance between prevention and treatment manifests itself in unsustainable contemporary programs where, for example, a strong case is put forth on behalf of drug packages for treating/de-worming people infected with a range of parasites on the current neglected tropical disease (NTD) list [3], while no mention is made of the fact that clean water and sanitation would prevent re-worming by a considerable list of intestinal parasites and soil-transmitted helminths following the needed de-worming via drugs. We note that hookworm suppression in the southern United States nearly 100 years ago featured both de-worming with drugs and the prevention of re-worming by provision of sanitary facilities [4]. The contemporary “Schistosomiasis Control Initiative” (SCI) [5] is focused on distribution of praziquantel and albendazole for de-worming to improve the lives of infected people and protect children from future disease. However, it is worrying to us that SCI does not have funds to tackle two of the key risk factors, clean water and sanitation, in the priority health statistics list for the GBD program [6],[7]. These examples illustrate the need for bridge building between the water and engineering sectors and the biomedically focused component of the health sector [8],[9]. Indeed, many engineering nongovernmental organizations and private donors are prioritizing, not neglecting, clean water and sanitation projects, but unfortunately undertake no follow-up evaluation of health consequences due to their minimal connection to the health sector [8],[9].

Beginning with the list of NTDs that defines the focus of this journal, we find that polyparasitism is the rule rather than the exception in many tropical communities. In an in-depth study of a village in the region of Man, western Côte d’Ivoire, Keiser et al. [10] found that two-thirds of the population harbored three or more parasites concurrently from a list of 12 parasites investigated that included four helminths (Ascaris lumbricoides, hookworm, Schistosoma mansoni, and Trichuris trichiura) and eight intestinal protozoa, the most common being Entamoeba coli, Blastocystis hominis, Endolimax nana, and Iodamoeba butschlii. It has also been found that among school-aged children across 56 communities in the region of Man, 19% of children had coinfections with S. mansoni and hookworm [11]. Some of the schools had coinfection rates with these two parasites exceeding 50%. It is important to note that these reports exclude malaria, which is also common in the same communities. Further, coinfection with malaria and HIV has recently been highlighted as a source of increased severity of both these diseases in sub-Saharan Africa, and there is a growing literature focused on coinfection with diverse combinations of helminths, HIV, malaria, and tuberculosis [12].

Many newly emerging diseases (e.g., avian influenza), as well as long established members of the NTD list (e.g., Japanese encephalitis) have links to either domestic or wild animals, or both [14]. Indeed, most human infectious diseases have animal origins. These linkages underscore the need for connection between human and veterinary medicine, since animal health plays an important role as a risk factor in the burden of human disease. There are also related policy implications derivable from selected studies of animal-derived human infection (e.g., brucellosis) where vaccination of cattle, for example, is more cost-effective than interventions on humans to prevent new infection [15].

Much criticism has been directed at the GBD program to date as a result of its use of a variety of adjustment and imputation schemes on sparse primary data for the purpose of providing “improved and less biased” statistics [6]. Everyone agrees about the pressing need for more extensive high-quality primary data on human disease in tropical countries, but the necessary political will and financial resources to develop and maintain the requisite data bases is missing. This constitutes an even more difficult problem when the integration of human and animal health is incomplete.

The Mathers et al. paper [7] “examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007.” We view the stated proposal as largely fine-tuning of an existing framework rather than an attempt to develop a much needed conceptual and methodological reformulation with related data collection activities that would yield a vastly more realistic picture of human disease burden. Seriously addressing comorbidity and the integration of human and animal health would represent a major stride forward in eliminating neglected environmental and sanitary issues, and would concomitantly bring NTDs into greater prominence. Equally important is the potential for establishing long-term revenue steams to finance primary data collection in the tropics by building on trade agreement surveillance requirements. The WTO may be a difficult partner to work with, but there are public health payoffs from a focus on trade-related health issues. While WHO may seem like the more natural institution through which to orchestrate the requisite primary data collection for the next generation of GBD reporting, WHO lacks the clout and basis of support needed at the highest levels of government to secure stable revenue streams needed to sustain such a system. The WTO, on the other hand, is more limited in human disease scope, but because of its focus on trade, it commands greater attention in establishing primary data collection platforms.



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