Research Article: Nilutamide

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Niraj S. Trasi, Phillip E. Fanwick, Lynne S. Taylor.


The crystal structure of nilutamide [systematic name: 5,5-dimethyl-3-[4-nitro-3-(trifluoro­meth­yl)phen­yl]imidazolidine-2,4-dione], C12H10F3N3O4, was determined at 150 K. The dihedral angle between the mean planes through the imidazoline [maximum deviation = 0.0396 (14) Å] and benzene rings is 51.49 (5)°. The mol­ecule exhibits inter­molecular hydrogen bonding via N—H⋯O inter­actions, resulting in the formation of chains parallel to the c axis.

Partial Text

For the structure of a related compound, see: Cense et al. (1994 ▶).