Date Published: June 17, 2016
Publisher: Public Library of Science
Author(s): Sébastien Bailly, Marie Destors, Yves Grillet, Philippe Richard, Bruno Stach, Isabelle Vivodtzev, Jean-Francois Timsit, Patrick Lévy, Renaud Tamisier, Jean-Louis Pépin, Friedemann Paul.
The classification of obstructive sleep apnea is on the basis of sleep study criteria that may not adequately capture disease heterogeneity. Improved phenotyping may improve prognosis prediction and help select therapeutic strategies. Objectives: This study used cluster analysis to investigate the clinical clusters of obstructive sleep apnea.
An ascending hierarchical cluster analysis was performed on baseline symptoms, physical examination, risk factor exposure and co-morbidities from 18,263 participants in the OSFP (French national registry of sleep apnea). The probability for criteria to be associated with a given cluster was assessed using odds ratios, determined by univariate logistic regression. Results: Six clusters were identified, in which patients varied considerably in age, sex, symptoms, obesity, co-morbidities and environmental risk factors. The main significant differences between clusters were minimally symptomatic versus sleepy obstructive sleep apnea patients, lean versus obese, and among obese patients different combinations of co-morbidities and environmental risk factors.
Our cluster analysis identified six distinct clusters of obstructive sleep apnea. Our findings underscore the high degree of heterogeneity that exists within obstructive sleep apnea patients regarding clinical presentation, risk factors and consequences. This may help in both research and clinical practice for validating new prevention programs, in diagnosis and in decisions regarding therapeutic strategies.
Obstructive sleep apnea (OSA) is a major global health concern, causing considerable cardiovascular and metabolic morbidity and mortality . Although mainly defined by the apnea + hypopnea index (AHI) , OSA is nowadays considered a complex, heterogeneous and multi-component condition. It is increasingly recognized that the presence of symptoms, mainly sleepiness but also comorbidities such as cardiovascular and metabolic disease, substantially contributes to prognosis .
Our study is the largest cluster analysis to date conducted in the field of mostly obese patients with obstructive sleep apnea syndrome. Previous studies addressing OSA clusters were limited by their small sample size and relatively low number of variables included in the analysis. In our large group of more than 18,000 OSA patients from a prospective national registry, patients within each cluster varied considerably in age, BMI, symptoms, co-morbidities, and risk exposures. Our data collection was multisite both from large academic sites and smaller private clinical practices implying that our results have high external validity and are highly generalizable. Our findings underscore the significant heterogeneity that exists between OSA patients at time of diagnosis.
Our study that included 18,000 unselected OSA patients in a cluster analysis exploiting a large set of variables collected at time of diagnosis. We identified 6 distinct clusters of obstructive sleep apnea. Our findings underscore the high degree of heterogeneity that exists within obstructive sleep apnea patients regarding clinical presentation, risk factors and consequences. Obviously, these clusters need to be evaluated to determine whether thy have long-term prognostic implications.