Date Published: April 4, 2013
Publisher: Public Library of Science
Author(s): Olivier Terrier, Jean-Christophe Bourdon, Manuel Rosa-Calatrava, Glenn F. Rall.
In response to extra- or intracellular stresses, the cellular gatekeeper p53 is able to integrate multiple diverse signals to determine the outcome of cell fate, by regulating the expression of numerous responsive genes , . The tumor suppressor p53 has been extensively investigated in the field of cancer research , however there are reports it has a broader role in several other biological processes, such as metabolism, reproduction, or the immune response –.