Research Article: p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?

Date Published: April 4, 2013

Publisher: Public Library of Science

Author(s): Olivier Terrier, Jean-Christophe Bourdon, Manuel Rosa-Calatrava, Glenn F. Rall.


Partial Text

In response to extra- or intracellular stresses, the cellular gatekeeper p53 is able to integrate multiple diverse signals to determine the outcome of cell fate, by regulating the expression of numerous responsive genes [1], [2]. The tumor suppressor p53 has been extensively investigated in the field of cancer research [3], however there are reports it has a broader role in several other biological processes, such as metabolism, reproduction, or the immune response [1]–[4].




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