Research Article: Predicting chromosome 1p/19q codeletion by RNA expression profile: a comparison of current prediction models

Date Published: February 15, 2019

Publisher: Impact Journals

Author(s): Zhi-liang Wang, Zheng Zhao, Zheng Wang, Chuan-bao Zhang, Tao Jiang.


Background: Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might influence the clinical management for doctors. Here, we attempted to explore an RNA sequencing computational method to detect 1p/19q status.

Partial Text

Glioma is the most common and deadliest malignant primary brain tumor in adults [1]. Oligodendroglial tumors, including oligodendrogliomas and oligoastrocytomas, are the second common type of glioma [2–5]. Chromosome 1p/19q codeletion, complete deletion of both the short arm of chromosome 1 and the long arm of chromosome 19, is the specific hallmark of oligodendrogliomas. The frequency of this genetic aberration in oligoastrocytoma and oligodendroglioma are 50%~70% and 70% ~80%, respectively [6].

With the rapid expansion of multi-platform integrated analysis of glioma, molecular markers have greatly facilitated the understanding of the genetic progress underlying the progress of cancer and provided key insights on precision medicine. The status of chromosome 1p/19q is one of the most crucial molecular markers in glioma, which has shown well-established association with the diagnosis and prognosis of patients [36].




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