Date Published: June 30, 2017
Publisher: Tabriz University of Medical Sciences
Author(s): Eskandar Moghimipour, Anayatollah Salimi, Sahar Changizi.
Purpose: The objective of the present study is to formulate and evaluate a new microemulsion (ME) for topical delivery of griseofulvin.
Griseofulvin is an anti-fungal agent used in the treatment of dermatophytic fungi among different species in the general Microsporum, Trychophyton and Epidermophyton.1,2 Also, it has been shown effective for treatment of several inflammatory skin diseases.3 Currently, however, because of numerous oral complications, its application is restricted. When used topically, the drug is directly transported to the location and forms a high concentration of drug in the lesion. Topically applied griseofulvin has been reported to be a better prophylactic agent than both miconazole and clotrimazole.4,5
Isopropyl myristate, oleic acid, span20, transcutol-P and tween80 were purchased from Merck Chemical company (Germany). Diethylene glycol monoethyl ether (Transcutol P), Caprylocaproyl macrogoglycerides (Labrasol), pleurol oleic were kindly gifted by GATTEFOSSE Company (France), and griseofulvin powder was obtained from Darou Pakhsh company (IR Iran). The effect of variables on different responses was assessed by experimental design using Minitab 17. Ternary phase diagrams were plotted Sigma plot 12.
Internal structure of microemulsions such as cubic, lamellar and hexagonal liquid crystal structures were evaluated by different methods including SAXS. Any alteration in water, oil and surfactant content of microemulsions significantly changed their structures. The results indicated that the presence of liquid crystal structure may affect their release, viscosity and other characteristics of the formulations. DSC technique revealed the presence of bound and free water in microemulsions.
This paper is extracted from Pharm. D. thesis (Changizi, S), and financial support was provided by Ahvaz Jundishapur University of Medical Sciences. The authors are very thankful to Faratin company manager (Taheri, M, Iran) for providing gratis samples of Labrasol, Transcutol P, Pleurol Oleic from GATTEFOSSE (France).
The authors declare no conflict of interest.