Research Article: Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus

Date Published: April 9, 2019

Publisher: Public Library of Science

Author(s): Christopher G. Németh, Christoph Röcken, Reiner Siebert, Jörg Wiltfang, Ole Ammerpohl, Volker Gassling, Hiromu Suzuki.

http://doi.org/10.1371/journal.pone.0215055

Abstract

Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate is still only about 50 percent. Chronic inflammation is one of the hallmarks of carcinogenesis. Until now, little is known about the premalignant status of oral lichen planus (OLP) and molecular alterations in OLP are still poorly characterized. Our study aims to delineate differential DNA methylation patterns in OLP, OSCC, and normal oral mucosa.

Partial Text

Head and neck squamous cell carcinoma (HNSCC affects about 700,000 individuals per year currently making it the sixth leading cause of cancer-related mortality worldwide [1, 2]. Among these, HNSCC of the lip, oral cavity and pharynx have been estimated to account for 529,500 incident cases and 292,300 deaths in 2012 [2]. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate of patients carrying these tumours is still only about 50 percent [2]. Thus, further insight into HNSCC pathogenesis is urgently needed to improve preventive and therapeutic strategies.

By assaying more than 450,000 CpG sites in the genome, we studied the patterns of altered methylation between normal oral mucosa, OLP, and OSCC. In this analysis, distinct patterns of altered methylation arise that may contribute to a better understanding of OSCC and its carcinogenesis.

 

Source:

http://doi.org/10.1371/journal.pone.0215055

 

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