Date Published: December 14, 2009
Publisher: Public Library of Science
Author(s): Paola Sebastiani, Monty Montano, Annibale Puca, Nadia Solovieff, Toshio Kojima, Meng C. Wang, Efthymia Melista, Micah Meltzer, Sylvia E. J. Fischer, Stacy Andersen, Stephen H. Hartley, Amanda Sedgewick, Yasumichi Arai, Aviv Bergman, Nir Barzilai, Dellara F. Terry, Alberto Riva, Chiara Viviani Anselmi, Alberto Malovini, Aya Kitamoto, Motoji Sawabe, Tomio Arai, Yasuyuki Gondo, Martin H. Steinberg, Nobuyoshi Hirose, Gil Atzmon, Gary Ruvkun, Clinton T. Baldwin, Thomas T. Perls, Joanna Mary Bridger. http://doi.org/10.1371/journal.pone.0008210
Abstract: The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered.
Partial Text: Exceptional longevity (EL) in humans, defined as living to extreme old ages such as 100 years and older, is strongly familial – and the factors that facilitate such exceptional survival have broad public health significance including a marked delay in age-related disability – and certain age-related diseases –. Genetically, exceptional longevity is presumed to be a complex trait –. Several candidate gene association studies have been successful in discovering longevity-associated genes in humans. However, these variants have been mainly related to lipoprotein metabolism –, FOXO proteins , , and insulin/IGF-1 signaling  It is likely that many more genetic modifiers of human aging have yet to be discovered .