Research Article: (S)-5-Hexyl-1-[(S)-2-hydr­oxy-1-phenyl­ethyl]-4-meth­oxy-1H-pyrrol-2(5H)-one

Date Published: May 01, 2009

Publisher: International Union of Crystallography

Author(s): Jian-Feng Zheng, Li-Jiao Jiang, Jian-Nan Guo.

http://doi.org/10.1107/S1600536809014160

Abstract

The title compound, C19H27NO3, was obtained by the reaction of (3S,7aR)-7a-hexyl-7-meth­oxy-3-phenyl-2,3-dihydro­pyrrolo[2,1-b]oxazol-5(7aH)-one and triethyl­silane using titanium(IV) chloride as catalyst. In the mol­ecule, the phenyl and dihydro­pyrrolone rings form a dihedral angle of 83.8 (1)°. O—H⋯O hydrogen-bonding inter­actions lead to the formation of a chain parallel to the a axis.

Partial Text

For the bioactivity of methyl tetramates, see: Royles (1995 ▶). For the synthesis, see: Jiang et al. (2009 ▶).

 

Source:

http://doi.org/10.1107/S1600536809014160

 

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