Research Article: Study of Thermal Analysis Behavior of Fenbendazole and Rafoxanide

Date Published: June 30, 2017

Publisher: Tabriz University of Medical Sciences

Author(s): Ali Kamal Attia, Ahmed Sayed Saad, Manal Sami Alaraki, Eman Saad Elzanfaly.


Thermal analysis techniques have been applied to study the thermal behavior of fenbendazole (Fen) and rafoxanide (Raf). Semi-empirical molecular orbital calculations were used to confirm these results.

Partial Text

Fen is chemically named as methyl [5-(phenylsulfanyl)-1H-benzoimidazol-2-yl] carbamate.1 It is a benzimidazole carbamate anthelmintic utilized in veterinary medicine as antiparasitic drug.2

The thermal behavior of Fen and Raf was studied as the first trial in this work using different thermal analysis techniques. The results were confirmed using MO calculations to obtain the correct path way of thermal decomposition of these drugs.

The authors would like to express their gratitude to the National Organization for Drug Control and Research (NODCAR, Egypt) and Department of Analytical Chemistry at Faculty of Pharmacy (Cairo University, Egypt) for providing instruments and the means necessary to accomplish this work.

Not applicable.

The authors declare no conflict of interests.




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