Research Article: Studying the Effect of Sertraline in Reducing Aggressive Behavior in Patients with Major Depression

Date Published: June 30, 2017

Publisher: Tabriz University of Medical Sciences

Author(s): Alireza Farnam, Arezoo MehrAra, Hossein Dadashzadeh, Golamreza Chalabianlou, Salman Safikhanlou.


Purpose: Depression causes dysfunction in various spheres of individual and social life, which is now considered as the fourth-leading cause of the global disease burden. Given that violence and aggression associated with depression in the community cause serious damage to the family, the prediction, early detection and effective treatment of aggressive and violent behavior are essential. The present study compared the severity of aggression before and after treatment with sertraline in patients with major depression.

Partial Text

Mental disorder is an illness with psychological and behavioral protests which cause considerable confusion in the different functional areas and is developed as a result of biological, social, psychological, genetic, physical or chemical disorders. According to the revised version of the fourth edition of the Diagnostic and Statistical book of DSM-IV-TR, mental disorders contain 17 main categories (children’s disorders, mood etc) and 375 disorders (major depression and schizophrenia etc.).1

This study is an interventional type with a population of depressed patients having aggressive behaviors, referred to psychiatric clinics affiliated with the University of Medical Sciences during 2015 to 2016. The method used was simple random sampling and it included 23 samples.

The average age of participants was 33.91 with a standard deviation of 14.8 and the minimum and maximum ages of 21 and 40 years respectively. Mean age was 34.63 years with a standard deviation of 8.06 and the average age of men was 30.50 years old with a standard deviation of 8.81.

Our research confirmed the study of Fava and Rosenbum (1998) who concluded that Sertraline was effective in the reduction of aggressive attacks and controlling the anger and increased it significantly.10

Obtained results in this research support the effect of Sertraline on reduction of severity of depression, reduction of severity of symptoms of aggression and anger (state of anger, anger feeling, and the tendency to express anger verbally), increased control of external anger and significantly increased control of internal anger. Hence, Sertraline can be found effective in the treatment of patients with depression and aggressive behaviors.

All participants and subjects who helped in the collection and codification of this article are acknowledged.

Not applicable.

The authors declare no conflict of interests.




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