Research Article: Tandem ChoRE and CCAAT Motifs and Associated Factors Regulate Txnip Expression in Response to Glucose or Adenosine-Containing Molecules

Date Published: December 22, 2009

Publisher: Public Library of Science

Author(s): Fa-Xing Yu, Yan Luo, Stefan Wölfl.

Abstract: Thioredoxin interacting protein (Txnip) is a multifunctional protein involved in regulation of cell cycle events and cellular metabolism. The expression of Txnip is known to be induced by glucose, adenosine-containing molecules, and other physiological cues; however, the underlying regulatory mechanisms remain elusive.

Partial Text: Thioredoxin interacting protein (Txnip, also known as VDUP1 and TBP-2) is involved in many cellular and physiological processes [1]–[3]. First, Txnip can regulate cellular redox state by inhibiting the activity of thioredoxin [2], [4]–[6]. Second, Txnip is a candidate of tumor suppressors, as it can suppress cell cycle progression [7]–[13]. Third, suggesting a role in cell differentiation, the development of natural killer cells in Txnip deficient mice is disrupted [14]. Fourth, Txnip can promote apoptosis by modulating the function of the apoptosis signal-regulating kinase 1 (ASK1) [5], [15]. Finally, a wealth of accumulated information suggests an intimate involvement of Txnip in regulating glucose and lipid metabolism [16]–[29].



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