Date Published: December 22, 2009
Publisher: Public Library of Science
Author(s): Fa-Xing Yu, Yan Luo, Stefan Wölfl. http://doi.org/10.1371/journal.pone.0008397
Abstract: Thioredoxin interacting protein (Txnip) is a multifunctional protein involved in regulation of cell cycle events and cellular metabolism. The expression of Txnip is known to be induced by glucose, adenosine-containing molecules, and other physiological cues; however, the underlying regulatory mechanisms remain elusive.
Partial Text: Thioredoxin interacting protein (Txnip, also known as VDUP1 and TBP-2) is involved in many cellular and physiological processes –. First, Txnip can regulate cellular redox state by inhibiting the activity of thioredoxin , –. Second, Txnip is a candidate of tumor suppressors, as it can suppress cell cycle progression –. Third, suggesting a role in cell differentiation, the development of natural killer cells in Txnip deficient mice is disrupted . Fourth, Txnip can promote apoptosis by modulating the function of the apoptosis signal-regulating kinase 1 (ASK1) , . Finally, a wealth of accumulated information suggests an intimate involvement of Txnip in regulating glucose and lipid metabolism –.