Date Published: August 19, 2013
Publisher: BioMed Central
Author(s): Michele Columbo, Bruce Wong, Reynold A Panettieri, Albert S Rohr.
There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients’ perception about the effect of this treatment. We studied whether the fraction of exhaled nitric oxide is affected by multiple allergen immunotherapy in polysensitized adult subjects with allergic rhinitis. We also looked for associations between exhaled nitric oxide and subjects’ demographics, symptom scores, and pulmonary function tests.
Twenty adult, polysensitized subjects with seasonal and perennial allergic rhinitis who chose to undergo allergen immunotherapy were enrolled. They were evaluated at baseline, and 4, 8, 12, 24, and 52 weeks later. Exhaled nitric oxide was reported as the mean of triplicate determinations.
Our results indicate that multiple allergen immunotherapy did not affect exhaled nitric oxide levels and such levels did not correlate with subjects’ demographics and pulmonary function tests. However, exhaled nitric oxide was associated with rhinoconjuctivitis and asthma symptom scores at the end of the study.
In polysensitized adult subjects with allergic rhinitis, exhaled nitric oxide levels are unaffected by multiple allergen immunotherapy.
FENO: Fraction of exhaled nitric oxide; IT: Immunotherapy; ACT: Asthma control test; ARCS: Allergic rhinoconjunctivitis symptoms; BMI: Body mass index.
All authors declare that they have no competing financial interests. This study was funded by the Sharpe-Strumia Research Foundation of the Bryn Mawr Hospital, Bryn Mawr, PA, USA (SSRF 2007–05, 2008–08, 2010–09).
MC participated in the study design, acquisition, interpretation and analysis of the data, in drafting and revising the manuscript. BW participated in the analysis, interpretation of the data, and in revising the manuscript. RAP participated in the interpretation of the data, and in revising the manuscript. ASR participated in the study design, acquisition, interpretation of the data, and in revising the manuscript. All authors approved the final version of this manuscript.