Research Article: The Effect of Taraxacum officinale Hydroalcoholic Extract on Blood Cells in Mice

Date Published: July 12, 2012

Publisher: Hindawi Publishing Corporation

Author(s): Mehrdad Modaresi, Narges Resalatpour.

http://doi.org/10.1155/2012/653412

Abstract

Objectives. Dandelion (Taraxacum officinale) is a herbaceous perennial plant of the family Asteraceae and has medicinal and culinary uses. Dandelion has been used as a remedy for anemia, purifing the blood, and providing immune modulation. Therefore, the aim of this study was to investigate the effect of hydro alcoholic extract on blood cells in mice. Methods. Five groups each including ten adult female (Balb/C) mice weighing 30 ± 5 g were chosen. Normal saline was administered as placebo for group, and dandelion hydro alcoholic extract in doses of 50,100, and 200 mg/kg was injected intraperitoneally for 20 days to test groups and the last group was control group.WBC, RBC, HB, HCT, platelet, and other cells were measured with automated cell counter.
Main Results. The number of RBC and the rate of HB in three doses of 100 and 200 mg/kg significantly increased (P < 0.05). As compared with control group, the number of WBC in three doses of 50, 100, and 200 mg/kg increased, but it was significantly in 200 mg/kg dandelion treated group as compared with control group(P < 0.05). The rate of platelet in three doses of 50, 100 and 200 mg/kg significantly decreased as compared with control group (P < 0.01). 3 doses of dandelion increased lymphocyte numbers significantly compared with controls. Conclusion. The study indicates efficacy of dandelion extract on RBC and HB in doses of 50, 100, and 200 mg/kg and in 200 mg/kg on WBC to achieve normal body balance.

Partial Text

History of using herbs to treat diseases and health gain has been common in human societies. Many researchers in last years had proved that herbs such as dandelion have considerable effects on treatment of disease. Taraxacum officinale is from the family Asteraceae [1].This hardly perennial herb usually has deeply toothed. Hairless leaves, 5–30 cm long and 1–10 cm wide. It grows 3–35 cm in height, forming a rosette of leaves at ground level. It has single, golden yellow flowers on straight. Leafless hollow stems, which emerge from the centre of the rosette. Each flower consists of a collection of florets. Flowers are produced from early spring until late autumn. When the florets mature, they produce downy seeds, which are easily dispersed by the wind [2] Dandelion plants have tap roots, tapering from 2 to 3 cm wide and at least 15 cm in length. Roots are fleshy and brittle, and are a dark brown color on the outside and white on the inside. Dandelion, Taraxacum officinale, was native to Europe but now can be found throughout the northern temperate zones [2] Dandelion is a rich source of vitamins and minerals and is particularly high in vitamins A and C and iron, carrying more iron and calcium than spinach [2] The folk medicines of China, India, and Russia have recognized dandelion’s effect as a liver tonic. Traditional Chinese medicine combines dandelion with other herbs to treat hepatitis [3], they used it to enhance the immune response to upper respiratory tract infections, bronchitis and pneumonia, and as a topical compress to treat mastitis [4]. Also it is used in the treatment of anemia and inflammation [5]. It used in treatment of jaundice, toxity, purifying the blood, fever, eye problems, gastrointestinal problems osteoarthritis, eczema, and cancer of uterus and breast in women [3].

Five groups each including ten adult female (Balb/C) mice weighing 30 ± 5 g were chosen. Normal saline was administered as placebo for group and dandelion hydro alcoholic extract in doses of 50, 100, and 200 mg/kg was injected intraperitoneally for 20 days to test groups and the last group was control group. WBC, RBC, HB, HCT, platelet, and other cells were measured with automated cell counter. For the statically calculation, we used ANOVAs and Duncan tests and the amount of P < 0.05 were considered significant. Comparison of red blood cells between control and experimental groups showed significant increase of red blood cells in experimental group 2 (treated with a dose 100 mg/kg) and 3 (treated with a 200 mg/kg) than the control group (P < 0.05). Figure 1 shows the results of this study.   Source: http://doi.org/10.1155/2012/653412

 

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