Research Article: The Genes of Antimicrobial Peptides for the Therapy of Intracellular Infections

Date Published: April , 2009

Publisher: A.I. Gordeyev

Author(s): V. N. V. N. Lazarev.



Partial Text

Resistance to antibiotics is of great social and economic importance and is regarded as a threat to the national security of any country and the global community as a whole. Among the bacterial agents of different infections, resistance to some antibiotics can reach 98%. Infections caused by antibiotic-resistant strains are distinguished by their significant duration, they often require hospitalization, they increase the length of hospital stay, and they often worsen the prognosis for a disease [1]. If the chosen medicines turn out to be ineffective, the doctors have to use second- or third-order medicines, which are often rather expensive, less safe, and not always available. All these facts increase direct and indirect economic expenditures, as well as cause a risk of antibiotic-resistant strain propagation. Causative agents of intracellular infections such as mycoplasmas and chlamydiae are characterized by high antibiotic resistance. Treating mycoplasmosis and clamidiosis with a wide range of antibiotics is almost ineffective due to the quick formation of resistance to these medicines, and, as a result, the development of virus persistence in the organism.