Date Published: June 30, 2017
Publisher: Tabriz University of Medical Sciences
Author(s): Roghiyeh Pashaei-Asl, Fatima Pashaei-Asl, Parvin Mostafa Gharabaghi, Khodadad Khodadadi, Mansour Ebrahimi, Esmaeil Ebrahimie, Maryam Pashaiasl.
Purpose: Ginger is a natural compound with anti-cancer properties. The effects of ginger and its mechanism on ovarian cancer and its cell line model, SKOV-3, are unclear. In this study, we have evaluated the effect of ginger extract on SKOV-3.
Ovarian cancer is the main reason of death from gynaecological malignant tumors, worldwide. Although there are advanced improvements in surgical techniques and accurately designed chemotherapy regimens, reversion remains practically unavoidable in patients with progressive disease.1,2 Ovarian cancer is the fifth cause of death related to the cancer in women and covers a histologically and genetically a wide range of malignancies, containing those of epithelial, sex cord-stromal and germ cell source.3 In the year 2016, about 22,280 new cases with ovarian cancer were diagnosed and approximately 14,240 women died because of this cancer in the United States.4
In this study, we investigated the effects of the ginger extract on ovarian cancer cell line and used bioinformatics analysis to find out the most accurate and reliable results. Ginger (Zingiber officinale), a natural poly-phenol constituent from rhizomes and ginger root, is extensively used as a spice or a traditional medicine. Researchers have been consistently revealed anti-cancer activities of phenolic substance in vegetables and fruits both in vitro and in vivo.17,24-27 Recently, different publications reveled the anticancer effect of ginger on various human cancer cell lines such as breast cancer (BC), prostate adeno-carcinoma (PC-3), Hela (Human cervical cancer), lung non-small cancer (A549), and colon cancer.28-32 Weng and the colleagues reported that 6-Shogaol and 6-gingerol efficiently block invasion and metastasis of hepatocellular carcinoma by different molecular mechanisms.26
Our study revealed that p53 expression is the main reason for the cytotoxicity effects of ginger in ovarian cancer cells and the cause of cell death in SKOV-3 cells. Bioinformatics analysis help to confirm and get more accurate and reliable results driven from ginger effect on the cell line and p53 expression. The data outlined the key co-expressed genes and co-expressed network of P53, as the key transcription factor induced by ginger extract.
The authors thank Faculty of Advanced Medical Science of Tabriz University for the support. This work is funded by the Women’s Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
The authors declare no conflict of interests.