Research Article: The Schistosomiasis Research Agenda—What Now?

Date Published: February 27, 2008

Publisher: Public Library of Science

Author(s): Jeffrey M. Bethony, Alex Loukas, Juerg Utzinger

Abstract: None

Partial Text: As relatively new schistosomiasis researchers, we awaited with eagerness the publication of the “Schistosomiasis Research Agenda” (SRA) put forward by Colley and Secor in the December 2007 issue of PLoS Neglected Tropical Diseases[1]. The SRA is a comprehensive, well-organized list of research activities that reflects the impressive diversity of interests that make up current schistosomiasis research. Colley and Secor went to admirable lengths to solicit the interests of researchers the world over, with special efforts to solicit the opinions of scientists in countries or regions where schistosomiasis is endemic, such as Brazil, China, and Africa. Having attended some of these meetings (11th International Congress of Parasitology, held in Glasgow, United Kingdom in August 2006; and the 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene, held in Atlanta, United States in November 2006) and received the e-mails, we are confident that the SRA indeed reflects the richness and breadth of current schistosomiasis research.

As noted by Colley and Secor [1], the diversity of backgrounds and interests in schistosomiasis, while enriching the field, may have also led to a “divisiveness” that has harmed its progress. In our opinion, there has been no greater area of divisiveness in schistosomiasis research than the debate on the use of chemotherapy versus vaccines for controlling schistosomiasis [8]–[12]. The debate did not result in a “fruitful reorientation of schistosomiasis research” as proferred [8], but has solidified researchers into the simplistic camps of “for” and “against” vaccines [7]. Furthermore, although we agree that there is much diversity in the field of schistosomiasis research, we do not feel that this diversity is inherently harmful. Perhaps even more troubling is the chronic discord within disciplines, whether it is epidemiology, immunology, genomics, proteomics, or control.

Rather than commenting on the exhaustive list of interests spanned and the numerous combinations of research interests and disciplines possible, we have instead chosen to discuss mechanisms by which the diverse interests of the SRA might be integrated into a potential way forward for the field. We feel that this is best accomplished by looking outside of schistosomiasis to fields in which similar diversities—but not divisiveness—exist and researchers work harmoniously and productively. Box 1 highlights some examples of networks that are considered to be highly successful by many of their respective members. For instance, malaria research is a large and highly competitive field, but a number of networks and foundations exist to foster collaboration, communication, and interactions amongst members. This is best exemplified by BioMalPar, which has been a great success for the malaria community and laboratories in both Europe and endemic countries. Many consider the flagship of BioMalPar to be its PhD program, which is centered on joint supervision of doctoral students and genuine time spent in multiple laboratories in different countries. Their scientific conferences and the degree of openness amongst malaria groups (many of which were traditionally rivals) are considered to be truly impressive by malariologists.

The successful networks highlighted above have one thing in common: they are well funded. However, this was not always the case—these researchers had to come together, agree on a granting agency to target, and develop a suitable agenda by which to solicit funding. We suggest that the SRA is the place to start a similar effort for schistosomiasis with the following objectives: (a) fostering interdisciplinary methods; (b) standardizing research protocols; (c) elevating the profile of schistosomiasis within the global health community; (d) creating repositories of biomaterial; and (e) utilizing expertise outside of schistosomiasis. An example of a well-funded cooperation within schistosomiasis already exists. The Biomedical Research Institute (BRI) in Maryland, US is a facility that supports schistosomiasis research through the provision of parasite material and a repository for reagents. The BRI schistosomiasis program is funded by National Institutes of Health, highlighting to the community that granting bodies are prepared to fund schistosomiasis research and nurture collaborative efforts.

We need to build upon the momentum created by the SRA. As a start, we should not consider the SRA as a static document, nor the end of a process, but the start of one. Indeed, one of the best aspects of the SRA was the transparent manner in which it was created and composed, which involved an extensive emailing list, frank conversations between researchers, lively meetings of the schistosomiasis community at major conferences, and the understanding that the SRA would not promote any one group of researchers or area of research, but was a voice for the entire community. With this infrastructure already in place, we should come together in an effort to secure funding that does not directly benefit any one of our research programs, but further unifies the community, accelerating its “recovery” to that warranted by the severity of the disease itself.



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