Date Published: December 8, 2009
Publisher: Public Library of Science
Author(s): Anne M. Presanis, Daniela De Angelis, Angela Hagy, Carrie Reed, Steven Riley, Ben S. Cooper, Lyn Finelli, Paul Biedrzycki, Marc Lipsitch, Lone Simonsen
Abstract: Marc Lipsitch and colleagues use complementary data from two US cities, Milwaukee and New York City, to assess the severity of pandemic (H1N1) 2009 influenza in the United States.
Partial Text: The H1N1 2009 influenza (pH1N1) pandemic has resulted in over 209,000 laboratory-confirmed cases and over 3,205 deaths worldwide as of 11 September 2009 (http://www.who.int/csr/don/2009_09_11/en/index.html, accessed 14 September 2009), but national and international authorities have acknowledged that these counts are substantial underestimates, reflecting an inability to identify, test, confirm, and report many cases, especially mild cases. Severity of infection may be measured in many ways, the simplest of which is the case-fatality ratio (CFR), the probability that an infection causes death. Other measures of severity, which are most relevant to the burden a pandemic exerts on a health care system, are the case-hospitalization and case-intensive care ratios (CHR and CIR, respectively), the probabilities that an infection leads to hospitalization or intensive care unit (ICU) admission. In the absence of a widely available and validated serologic test for infection, it is impossible to estimate these quantities directly, and in this report we instead focus on the probabilities of fatality, hospitalization, and ICU admission per symptomatic case; we denote these ratios sCFR, sCHR, and sCIR respectively.
Table 2 shows the numbers of medically attended cases, hospitalizations, ICU admissions, and deaths in the two cities, with the Milwaukee data separated into the period (to May 20) for which we believe medically attended cases were consistently detected, and the period (to June 14) for which we consider only hospitalized cases, ICU admissions, and deaths.
We have estimated, using data from two cities on tiered levels of severity and self-reported rates of seeking medical attention, that approximately 1.44% of symptomatic pH1N1 patients during the spring in the US were hospitalized; 0.239% required intensive care or mechanical ventilation; and 0.048% died. Within the assumptions made in our model, these estimates are uncertain up to a factor of about 2 in either direction, as reflected in the 95% credible intervals associated with the estimates. These estimates take into account differences in detection and reporting of cases at different levels of severity, which we believe, based on some evidence, to be more complete at higher levels of severity. Without such corrections for detection and reporting, estimates are approximately two-fold higher for each level of severity. Using a second approach, which uses self-reported rates of influenza-like illness in New York City to estimate symptomatic infections, we have estimated rates approximately an order of magnitude lower, with a symptomatic sCHR of 0.16%, an sCIR of 0.028%, and an sCFR of 0.007%. In both approaches, the sCFR was highest in adults (in Approach 1, 18–64 y, while Approach 2 cannot distinguish whether it is higher in that group or in those 65y and older) and lowest in school-aged children (5–17 y). Data on children 0–4 and adults 65 and older were relatively sparse, making statements about their ordering more difficult. Nonetheless, these findings, along with surveillance data on the age-specific rates of hospitalization and death in this pandemic (http://www.cdc.gov/vaccines/recs/ACIP/downloads/mtg-slides-oct09/12-2-flu-vac.pdf), indicate that the burden of hospitalization and mortality in this pandemic falls on younger individuals than in seasonal influenza . A shift in mortality toward nonelderly persons has been observed in previous pandemics and the years that immediately followed them .