Research Article: Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers

Date Published: January 17, 2017

Publisher: Public Library of Science

Author(s): Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa, Carlos Zaragoza.

http://doi.org/10.1371/journal.pone.0170309

Abstract

We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients.

The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years’ experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer.

Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD.

Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

Partial Text

Bone metastasis occurs at high rates in primary lung cancer. After or during primary lung cancer treatment, bone metastases occur in about 10–40% of patients [1–6]. The most common site of bone metastases in primary lung cancer patients is the spine, especially the thoracic vertebrae [3, 7]. Vertebral metastases can cause pain progression, compression fractures, and neural disturbances such as paralysis, which consequently compromise patients’ quality of life (QOL) [3, 6, 8]. Therefore, early detection and treatment to preserve QOL should be considered for these patients [1, 5, 6, 8]. Currently, the most helpful diagnostic imaging methods are spinal magnetic resonance imaging (MRI) and whole-body positron emission tomography (PET) [8, 9]. However, these diagnostic imaging methods are not routine in the follow-up of lung cancer patients who have none of the typical symptoms [5].

Our retrospective study was approved by our institutional review board, and informed consent was waived (approval no. 636–3).

The total reading time of reader A was 1 h 41 min (3.4 min per case) and that of reader B was 1 h 50 min (3.7 min per case). The kappa statistic showed good reproducibility between the two readers for both assessments without CAD (0.672, p < 0.001) and with CAD (0.651, p < 0.001). The present study shows that our temporal 3D-CT subtraction CAD software can help radiologists to detect vertebral metastases, regardless of the osteolytic or osteoblastic nature of the lesions, during routine interpretation of a thoracic CT image for follow-up of primary lung cancer. Lung cancer regardless of the histopathological subtypes often occur bone metastasis. It causes skeletal related events defined as the need for radiotherapy or surgery, pathological fracture, spinal cord compression, and hypercalcemia [1, 3]. Vertebral metastases often result in pathological fracture or spinal cord compression, which can cause severe pain, paralysis, disturbance of gait, bladder and rectal disturbance. These complications cause significant morbidity and reduced QOL. Therefore, it is important for the physician and radiologist not to overlook them in routine check-up imaging even if a patient has no symptoms.   Source: http://doi.org/10.1371/journal.pone.0170309