Research Article: Tsetse Control and the Elimination of Gambian Sleeping Sickness

Date Published: April 29, 2016

Publisher: Public Library of Science

Author(s): Mike Lehane, Idriss Alfaroukh, Bruno Bucheton, Mamadou Camara, Angi Harris, Dramane Kaba, Crispin Lumbala, Mallaye Peka, Jean-Baptiste Rayaisse, Charles Waiswa, Philippe Solano, Steve Torr, Paul Andrew Bates.

Abstract: None

Partial Text: The two largest tests of tiny targets in G-HAT foci have been carried out in Uganda (G. fuscipes fuscipes) and Guinea (G. palpalis gambiensis). In Northern Uganda, a trial was performed over 500 km2 covering two HAT foci. Nearly 3,000 targets were deployed every six months giving an overall target density of 5.7/km2. In 12 months, tsetse populations declined by more than 90% [18]. In Guinea, the studies were used to determine the efficacy of adding vector control to screen-and-treat in the Boffa HAT focus. The focus was divided into two parts [9], and active screen-and-treat was carried out in the western part, whereas in the eastern part active screen-and-treat was combined with vector control. In the area with vector control, there was an overall 80% decrease in tsetse density resulting in a significant decrease of human tsetse contacts [9]. This was reflected in a decrease of disease incidence (from 0.3% to 0.1%; p < 0.01) with almost no new infections occurring (<0.1% in one year). In contrast, in the area with medical interventions but no vector control, incidence was ten times higher (>1%, p < 0.0001), and disease prevalence increased slightly (from 0.5 to 0.7%, p = 0.34) [9]. Source:


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