Research Article: Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Date Published: July 31, 2012

Publisher: Impact Journals LLC

Author(s): Mikhail V. Blagosklonny.

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Abstract

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?

Partial Text

Wt p53 can induce apoptosis, cell cycle arrest and senescence, which are sufficient to explain tumor suppression by p53 [1]. A recent paper in Cell described that these activities are dispensable for tumor suppression [2]. Mutant p53 (p533KR) that cannot cause arrest, senescence and apoptosis still suppressed tumors in mice [2, 3]. Why do then wt p53 induce apoptosis, cell cycle arrest and senescence? Before entertaining this intriguing question, I will focus on suppression of senescence (gerosuppression) by p53, overlapping with its anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects.

 

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