Research Article: Use of cyanoacrylate-based surgical adhesives associated to the macroporous tape in skin synthesis in rats1

Date Published: September 12, 2019

Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia

Author(s): João Ilgenfritz, Ricardo Dutra Aydos, Iandara Schettert Silva, Luiz Carlos Takita, Antônio Carlos de Abreu, Cynthia Alexia Cunha Silva, Karina Bossi Faleiros, Evair Moisés de Lima Santiago, Rondon Tosta Ramalho.


To compare the use of new cyanoacrylate surgical adhesive associated with macroporous tapes in cutaneous synthesis.

Male Wistar rats with a longitudinal incision of 4cm were used on the back, divided into four groups: GI used octyl-cyanoacrylate (Dermabond®), GII used N-2-butylcyanoacrylate, GIII used octyl-cyanoacrylate and macroporous tape and GIV used N-2-butyl cyanoacrylate and macroporous tape. On the fourteenth day, the rats were submitted to euthanasia, were divided in two parts, and a layer of skin subcutaneous tissue through an area of operative healing was removed. One part was submitted to the study of rupture strength with the use of tensiometer, and in the other part histological examination was performed.

No force test was similar between groups I and II, being different from groups III and IV (P <0.001), which were identical to each other (P> 0.05). The units were compared among the studied groups, and they were different with the use of macroporous tapes (P> 0.05).

The purpose of macroporous tapes is associated with CA adhesives in cutaneous tissues that provide more resistant scars. The use of a combination of macroporous tapes leads to complete re-epithelialization, without provoking foreign body reaction, has hemostatic properties and does not cause an absorptive reaction.

Partial Text

The wound healing process is a sophisticated mechanism dependent on several factors, including the extent and depth of an injury, which will determine a cicatricial response, and the more complicated or time-consuming wound occlusion will increase the chances of developing a wound of worse quality1.

This experimental research was evaluated by the Animal Use Ethics Committee (CEUA) of the Universidade Federal do Mato Grosso do Sul and all procedures were performed according to the Animal Experimentation Ethics Committee under protocol number 882/2017.

This experiment showed a similar index to the short-term dehiscence that can be observed in the literature, demonstrating that the adhesive is less efficient in areas of tension than the conventional suture, limiting its isolated use to areas of low tension. Ilgenfritz et al.14, when performing a similar experiment with the same N-2-butyl cyanoacrylate and Octyl-cyanoacrylate adhesive, found a total of 33.3% dehiscence with Octyl-cyanoacrylate alone and 41.6% with N-2-butylcyanoacrylate 14, and in this experiment 12.5% dehiscence was observed in group I and 25% in group II, groups where the adhesives were used in isolation.

The use of CA adhesives associated with macroporous tapes produces more resistant scars when compared to their isolated use.




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